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(PubMed) Parvanova A, Trillini M, Podesta MA, et al

The importance of Trp114 hTrxR1 for hTrx1 binding could be supported through kinetic analysis of a hTrxR1 W114A,U498C mutant, which did not produce a detectable activity in the Trx-assay (Table 2)

This iron-sequestering capability is particularly important because excess free iron directly enters cells, concentrates in mitochondria, disrupts oxidative phosphorylation, catalyzes lipid peroxidation, and ultimately leads to cell death

2000), was also induced by treatment with DPTA-NONOate
